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目的观察辛伐他汀治疗不稳定型心绞痛(UAP)的临床疗效及安全性。方法选择近年来收治的不稳定型心绞痛患者214例,根据前瞻性、随机化原则分为观察组和对照组各107例。对照组给予常规治疗:根据病情选用硝酸酯类、β受体阻滞剂、血管紧张素转化酶抑制剂、钙拮抗剂、抗血小板制剂、低分子肝素钙等综合治疗;观察组在对照组基础上加用辛伐他汀,初始剂量为10mg,1次/d,睡前顿服,疗程12周。疗程结束后观察两组临床疗效,心电图变化及药物不良反应。结果观察组显效56例(52.3%),有效48例(44.9%),无效3例(2.8%),总有效率97.2%;对照组显效34例(31.8%),有效38例(35.5%),无效35例(32.7%),总有效率67.3%;观察组显效率和总有效率均明显高于对照组,P<0.05。两组治疗期间均未出现明显不良反应,用药安全。结论辛伐他汀有明显的调脂作用及广泛的非调脂作用,可防止动脉粥样斑块进展,恢复血管内皮功能,抑制斑块中的炎症反应,稳定易损斑块,临床疗效及安全性均良好。
Objective To observe the clinical efficacy and safety of simvastatin in the treatment of unstable angina pectoris (UAP). Methods 214 cases of unstable angina pectoris admitted in recent years were divided into observation group and control group according to the principle of prospective and randomization. The control group were given routine treatment: nitrates, β-blockers, angiotensin-converting enzyme inhibitors, calcium antagonists, antiplatelet agents and low molecular weight heparin calcium were selected according to the condition. The observation group was basal in the control group Add simvastatin on the initial dose of 10mg, 1 / d, Dayton clothing before going to bed, treatment for 12 weeks. After the end of treatment, the clinical efficacy, ECG changes and adverse drug reactions were observed. Results The observation group was markedly effective in 56 cases (52.3%), effective in 48 cases (44.9%), ineffective in 3 cases (2.8%), the total effective rate was 97.2%; in the control group, 34 cases (31.8% , Ineffective in 35 cases (32.7%), the total effective rate was 67.3%. The effective rate and total effective rate in the observation group were significantly higher than those in the control group (P <0.05). No significant adverse reactions during the two groups during treatment, medication safety. Conclusion Simvastatin has obvious lipid-lowering effects and a wide range of non-lipid-lowering effects, can prevent the progression of atherosclerotic plaque, restore endothelial function, inhibit inflammatory reaction in plaque, stabilize vulnerable plaque, clinical efficacy and safety Sex is good.