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目的:探讨帕金森病(PD)患者血清中白介素-17(IL-17)、胱抑素C(Cys C)、同型半胱氨酸(Hcy)水平变化及其在病情评估中的应用。方法:选择2013年5月至2015年3月我院神经内科诊疗的91例PD患者作为研究组,根据简易智力量表评价标准将患者分为认知功能障碍(A组)和无认知功能障碍(B组);根据Hoehn-Yahr(H-Y)分期标准分为早期组、中期组和晚期组。另选择同期我院健康体检中心的健康志愿者53例作为对照组。检测受试者血清中IL-17、Cys C及Hcy的水平,进行统计分析。结果:与对照组相比,研究组患者血清中的各指标水平明显升高(P<0.05);同时,检测结果发现,A组患者血清中各指标水平显著高于B组(P<0.05);另外,随着H-Y分期的递增,PD患者血清中各指标水平明显升高(P<0.05)。结论:PD患者血清中的IL-17、Cys C、Hcy水平异常表达,在患有认知功能障碍的PD患者血清中的水平更高,同时,各指标对于不同H-Y分期的PD患者具有表征作用,对于临床诊断及病情评估具有重要意义,值得进行广泛推广。
Objective: To investigate the changes of serum interleukin-17 (IL-17), cystatin C (Cys C) and homocysteine (Hcy) levels in patients with Parkinson’s disease (PD) and their application in disease evaluation. Methods: Ninety-one PD patients diagnosed and treated in Department of Neurology in our hospital from May 2013 to March 2015 were selected as research group. Patients were divided into cognitive impairment (group A) and non-cognitive function (Group B). According to Hoehn-Yahr (HY) staging criteria, they were divided into early stage group, middle stage group and advanced stage group. In addition, we selected 53 healthy volunteers in our hospital during the same period as the control group. The serum levels of IL-17, Cys C and Hcy in the subjects were detected and statistically analyzed. Results: Compared with the control group, serum levels of all the indexes in the study group were significantly increased (P <0.05). At the same time, the serum levels of each group were significantly higher than those in the B group (P <0.05) In addition, the serum levels of PD in patients with PD increased significantly as the staging of HY increased (P <0.05). Conclusion: The abnormal expression of IL-17, Cys C and Hcy in serum of patients with PD is higher in the serum of PD patients with cognitive impairment, and the indexes of PD patients with different HY stage are characterized , For clinical diagnosis and disease evaluation of great significance, it is worth to be widely promoted.