大多数非酒精性肝硬化及慢性活动性肝炎病人使用强的松疗效是满意的,然而对有些病例却无效。强的松本身无糖皮质激素作用,它首先必须在肝内进行11位羟化而转变为强的松龙。强的松治疗的失败可能与病人在严重肝功能损害的情况下,不能将强的松转变为强的松龙有关。本文目的是研究肝硬化病人中,强的松转变为强的松龙与肝功能间的关系。方法:14例肝硬化,男性13例,女性1例,均经 Most patients with non-alcoholic cirrhosis and chronic active hepatitis using prednisone are satisfied, but in some cases they are ineffective. Prednisone itself glucocorticoid effect, it must first be in the liver 11 hydroxylation and into prednisolone. The failure of prednisone may be related to the inability of the patient to switch prednisone to prednisolone in the case of severe liver dysfunction. The purpose of this paper is to study the relationship between prednisone and prednisolone and liver function in cirrhotic patients. Methods: 14 cases of liver cirrhosis, 13 males and 1 females, all by