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胆汁酸盐输出泵(bile salt export pump,BSEP)是ATP结合盒超家族蛋白(ATP binding cassette,ABC)的一员,负责转运胆汁酸盐,并定位于肝细胞胆小管侧膜.在人类,BSEP缺陷可导致多种不同的胆汁淤积性疾病,包括遗传性肝病或获得性肝病.同时,BSEP也是Lith1致石基因的最可能的候选基因.由于胆汁酸盐在许多生理及病理生理过程中均有重要作用科学界对BSEP表达的调节机制的研究非常重视.本文对BSEP的转录调节及细胞内运输改变所致BSEP在胆小管侧膜的表达功能改变包括细胞内内质网以及细胞膜泛素化-蛋白酶介导的蛋白降解,BSEP的短期磷酸化、糖基化、泛素化及胆小管侧膜相关蛋白对BSEP的调节等相关研究进行综述.
The bile salt export pump (BSEP), a member of the ATP binding cassette ABC (ABC), is responsible for the transport of bile salts and localization on the hepatocellular ductal membrane. , BSEP deficiency can lead to a variety of different cholestatic diseases including hereditary or acquired liver disease, and BSEP is also the most likely candidate gene for Lith1-induced stone gene.Because bile salts are involved in many physiological and pathophysiological processes Plays an important role in the study of the regulatory mechanism of BSEP expression in the scientific community attaches great importance.In this paper, the transcriptional regulation of BSEP and intracellular transport changes in the expression of BSEP in the lateral tunica membrane function changes, including endoplasmic reticulum and cell membrane pan Related protein degradation, proteolysis-mediated proteolysis, short-term phosphorylation of BSEP, glycosylation, ubiquitination and regulation of BSEP by the membrane-associated membrane of the trophoblast.