本文介绍以蛋氨酸为原料合成 S-乙基-D,L-高半胱氨酸和以胱氨酸为原料合成S-氨乙基-L-半胱氨酸的简便方法。这二种氨基酸结构类似物可作为蛋氨酸、赖氨酸、苏氨酸以及异亮氨酸等菌种选育的代谢拮抗剂应用,以解除目的酸生物合成过程中关键酶的反馈抑制,从而达到提高这些氨基酸菌株的产酸率,增加氨基酸的产量。 In this paper, a simple and convenient method of synthesizing S-ethyl-D, L-homocysteine ​​from methionine and synthesizing S-aminoethyl-L-cysteine ​​from cystine was introduced. These two amino acid structural analogues can be used as metabolic antagonists for the selection of methionine, lysine, threonine and isoleucine to release feedback inhibition of key enzymes in the process of acid biosynthesis in order to achieve Increase the acid production rate of these amino acid strains, and increase the yield of amino acids.