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目的探讨系统性红斑狼疮(SLE)的妊娠时机及妊娠期治疗对SLE妊娠患者母婴结局的影响。方法回顾分析32例妊娠合并SLE患者的妊娠时机及妊娠期处理,观察其妊娠期SLE病情变化和母婴结局。结果选择性妊娠组20例中5例出现狼疮活动,非选择妊娠组12例均出现较为严重的狼疮并发症。非选择妊娠者SLE病情活动、妊娠丢失率、早产率明显高于选择妊娠者(P<0.05),新生儿体重显著低于选择妊娠者(P<0.05)。结论妊娠合并SLE患者母婴并发症发率高,选择合适妊娠时机及积极控制SLE病情是改善母婴结局的关键措施。
Objective To investigate the effect of pregnancy timing and gestational therapy on the outcome of maternal and infant in patients with SLE during the pregnancy of systemic lupus erythematosus (SLE). Methods Retrospective analysis of 32 cases of pregnant women with SLE during pregnancy and gestational timing treatment, observation of their pregnancy SLE changes and maternal and child outcomes. Results In the selective pregnancy group, 5 cases showed lupus activity in 20 cases, while non-selected pregnancy group showed more severe lupus complications. Non-selected pregnancy SLE disease activity, pregnancy loss rate, premature birth rate was significantly higher than the choice of pregnancy (P <0.05), neonatal weight was significantly lower than the choice of pregnancy (P <0.05). Conclusion The incidence of maternal and infant complications in pregnant women complicated with SLE is high. Choosing the appropriate timing of pregnancy and actively controlling SLE are the key measures to improve the maternal and infant outcomes.