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目的了解医院住院患者真菌感染现状,分析感染的危险因素,为合理制定医院感染控制措施提供依据。方法对某院2009-2012年626例深部真菌感染者进行回顾性调查分析。结果引起深部感染的真菌以白假丝酵母菌为主,占59.74%;呼吸内科、ICU病房、神经内科和肿瘤科住院患者较易发生医院真菌感染。真菌感染的部位以呼吸道最高,其次为泌尿道。长期大量应用广谱抗生素、年龄≥60岁老年患者、肿瘤化疗及各种侵入性操作是医院深部真菌感染的易感因素。结论临床上应加强患者呼吸系统监测,对于高危群体加强病原学检测,规范抗菌药物的使用,有助于控制医院真菌感染。
Objective To understand the current status of hospital inpatient fungal infection, analyze the risk factors of infection and provide the basis for the reasonable formulation of nosocomial infection control measures. Methods A retrospective analysis of 626 cases of deep fungal infection in a hospital from 2009 to 2012 was conducted. Results Candida albicans was the major cause of deep infection, accounting for 59.74%. Nosocomial fungal infections were more likely to occur in respiratory medicine, ICU wards, neurology and oncology inpatients. The site of fungal infection with the highest respiratory tract, followed by the urinary tract. Long-term large-scale use of broad-spectrum antibiotics, age ≥ 60 years old patients with cancer chemotherapy and invasive surgery is a hospital susceptible factor for deep fungal infections. Conclusions The respiratory system monitoring should be strengthened clinically. Etiological tests should be strengthened for high-risk groups to regulate the use of antimicrobial agents and to control the hospital’s fungal infections.