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旋毛虫分泌型抗原(ES)接种近交系小鼠大多可获得高水平的保护力。几种纯化的肌肉期幼虫蛋白亦可诱导保护性免疫,其中的一种分子量为43000(43k)糖蛋白为旋毛虫幼虫组1抗原(TSL-1)的成员,存在于肌肉期幼虫的分泌物及其表面,具有高度的免疫原性,能诱导保护性免疫力。作者根据该分子序列,合成了40—80、81—120和121—160三种40-mer的合成多肽(SP),用于旋毛虫疫苗的研究试验。
Trichinella secretory antigen (ES) vaccination inbred mice are mostly available to a high level of protection. Several purified muscle-stage larval proteins also induce protective immunity. One of the 43,000 (43k) glycoproteins is a member of Trichinella larvae group 1 antigen (TSL-1), present in muscle-stage larval secretions And its surface, with a high degree of immunogenicity, can induce protective immunity. Based on the molecular sequence, the authors synthesized three 40-mer synthetic peptides (SP) of 40-80, 81-120 and 121-160 for the study of Trichinella spiralis vaccine.