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It has been reported that centrally or peripherally administered pro-inflammatory cytokines induce the expression of Fos in the central nervous system.However, little is known about the effects of antigen-induced immune response on the expression of immediate early gene in the brain. In the present study, using Fos protein as a marker of activated neurons, we first investigated the functional circuitry in the brain of xeogenitic antigen-challenged rats. Four days following ip immunization with 5× 10~9 sheep red blood cells (SRBC), a specific antibody to SRBC in blood was detected with plaque-forming cell assay (PFC), and a robust and widespread induction of Fos in the brain was
It has been reported that centrally or peripherally administered pro-inflammatory cytokines induce the expression of Fos in the central nervous system. However, little is known about the effects of antigen-induced immune response on the expression of immediate early gene in the brain. In the present study, using Fos protein as a marker of activated neurons, we first investigated the functional circuitry in the brain of xeogenitic antigen-challenged rats. Four days following ip immunization with 5 × 10 ~ 9 sheep red blood cells (SRBC), a specific antibody to SRBC in blood was detected with plaque-forming cell assay (PFC), and a robust and widespread induction of Fos in the brain was