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据报导,食用蕨(Pteridium aquilinum)~*可引起牛膀胱癌。服用这一植物的实验动物,所引起广泛的变化大多数为癌变,但化学致癌物质,至今尚未分离出来。美国Wisconsin医科大学临床肿瘤部,将蕨的各提取部位,做致癌试验,发现其中有一个部位,具有最大的致癌力,并从此部位中分离出反丁烯二酸(Fumaric acid),琥珀酸、黄蓍甙、异槲皮甙和tiliroside。分离方法:将1公升蕨,用甲醇提取72小时,提取液在36°减压浓缩至糖浆状,再加入1升水混和,滤去沉淀,滤液用氯仿提取,水层再用正丁醇和2-丁酮(1∶1)混合液提取。提取液蒸干,溶于50毫升甲醇中,再加入200毫升乙醚混和,混和液过滤,蒸
It has been reported that Pteridium aquilinum ~ * can cause bovine bladder cancer. Most of the laboratory animals taking this plant cause cancer, but chemical carcinogens have not yet been separated. Department of Clinical Oncology, Wisconsin Medical University, USA, made the carcinogenic test on each extracted part of fern, and found that there is a part of it with the maximum oncogenic strength. Fumaric acid, succinic acid, Taraxoside, isoquercetin and tiliroside. Separation method: 1 liter of fern, extracted with methanol for 72 hours, the extract was concentrated under reduced pressure at 36 ° syrup, then add 1 liter of water, the precipitate was filtered off, the filtrate was extracted with chloroform, the water layer of n-butanol and 2- Butanone (1: 1) mixture. The extract was evaporated to dryness, dissolved in 50 ml of methanol, then add 200 ml of ether mixture, the mixture filtered, steaming