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目的讨论卵泡浆内单精子注射(intracytoplasmic sperm injection ICSI)与常规体外受精(in vitro fertilization IVF)受精方式对冷冻胚胎的解冻和移植后对临床妊娠的影响。方法慢速冷冻IVF或ICSI周期中剩余的优质胚胎,随后用快速融解法复苏后进行移植。观察各组胚胎冷冻解冻后的胚胎存活率及相关指标和临床妊娠率。结果50例患者中,IVF组为30个周期,妊娠4例,妊娠率为13.33%,ICSI组为20个周期,妊娠5例,妊娠率为25%,ICSI组冷冻胚胎优胚率、复苏后胚胎存活率、存活胚胎累积细胞数与复苏胚胎的累积细胞数百分比(累积细胞存活率)和存活胚胎累积评分与复苏细胞累积评分的百分比(累积评分率)有显著差异。结论冷冻胚胎的优胚率及复苏后获得高质量的胚胎是影响解冻胚胎移植的临床妊娠率重要因素。
Objective To discuss the effect of intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) on the clinical pregnancy after thawing and transplantation of frozen embryos. Methods Slowly freeze the remaining high quality embryos in the IVF or ICSI cycles and subsequently transplant them after resuscitation with rapid thawing. The survival rate of embryos after freezing and thawing in each group and related indicators and clinical pregnancy rate were observed. Results Among the 50 patients, the IVF group had 30 cycles with 4 pregnancies, the pregnancy rate was 13.33%, the ICSI group was 20 cycles and the pregnancy rate was 5%. The pregnancy rate was 25% There were significant differences in survival rate of embryos, cumulative number of viable embryos and cumulative number of surviving embryos (cumulative cell viability) and percentage of surviving embryos cumulative score (cumulative score) in surviving embryos. Conclusion The excellent embryo rate of frozen embryo and high quality embryo after resuscitation are the important factors affecting the clinical pregnancy rate of thawed embryo transfer.