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本实验研究了五味子油乳剂对中毒性肝损害的影响,主要结果如下。 1.对小鼠CCl_4中毒的预防和解毒作用连续4天静脉给药,对小鼠CCl_4中毒具有显著预防作用。当剂量加大,对血清谷-丙转氨酶阻抑作用增强,与对照组比较,P<0.001。小鼠两次CCl_4中毒后连续给药6天,可明显降低CCl_4中毒引起的高血清谷-丙转氨酶,高剂量组与对照组比较,P<0.001。进一步研究表明,连续两天给药后采用CCl_4使其中毒,给药组小鼠肝组织谷-丙转氨酶比对照组下降33.5%,P<0.01。 2.对家兔中毒性肝损伤病理组织学观察家兔
The experimental study of Schisandra oil emulsion on toxic liver damage, the main results are as follows. 1. The prevention and detoxification of mice with CCl 4 poisoning for 4 consecutive days of intravenous administration of CCl 4 poisoning in mice has a significant preventive effect. When the dose was increased, the inhibitory effect on serum glutamic-pyruvic transaminase was enhanced, compared with the control group, P <0.001. The mice were treated with CCl_4 poisoning twice for 6 consecutive days, which could significantly reduce high serum glutamic-pyruvic transaminase (ALT) induced by CCl_4 poisoning. Compared with the control group, the mice in the high dose group had a P <0.001. Further studies showed that CCl 4 poisoned mice after administration for two consecutive days. The level of glutamic-pyruvic transaminase in the liver of the mice in the treatment group decreased by 33.5% (P <0.01) compared with the control group. 2. Rabbit toxic liver injury pathological observation of rabbits