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目的探讨炔雌醇环丙孕酮与二甲双胍联合用于青春期多囊卵巢综合征(PCOS)患者的临床效果。方法 56例青春期PCOS患者随机分为观察组(n=28)与对照组(n=28),对照组给予炔雌醇环丙孕酮治疗,观察组在对照组基础上加用二甲双胍,连续治疗3个月经周期后对比两组患者临床效果。结果两组患者治疗前月经情况、F-G评分、Rosenfield评分、BMI比较差异均无统计学意义(P>0.05),经治疗,除对照组BMI无明显变化外,两组患者上述指标均显著降低(P<0.01或P<0.05),且治疗后观察组均显著低于对照组(P<0.01);治疗前两组LH、FSH、LH/FSH、T、E2及HOMA-IR比较差异无统计学意义(P>0.05),经治疗,两组患者LH、LH/FSH、T及HOMA-IR均显著降低(P<0.01),且治疗后观察组T、HOMA-IR显著低于对照组(P<0.01),两组FSH及E2水平治疗前后均无明显变化(P>0.05)。结论二甲双胍与炔雌醇环丙孕酮联合用于青春期PCOS的治疗,能够在有效改善患者月经周期的基础上,减轻胰岛素抵抗状态,降低血液胰岛素、睾酮水平,进而达到改善症状体征的目的,疗效可靠,值得推广。
Objective To investigate the clinical effect of ethinyl estradiol and cyproterone combined with metformin in adolescent patients with polycystic ovary syndrome (PCOS). Methods Fifty-six adolescent patients with PCOS were randomly divided into observation group (n = 28) and control group (n = 28), and ethinyl estradiol cyproterone treatment group. The observation group was treated with metformin on the basis of the control group After three menstrual cycles compared the clinical effect of two groups of patients. Results There were no significant differences in menstruation, FG score, Rosenfield score and BMI between the two groups before treatment (P> 0.05). After treatment, except the BMI in the control group, the above indexes were significantly decreased P <0.01 or P <0.05). After treatment, the observation group was significantly lower than the control group (P <0.01). There was no significant difference in LH, FSH, LH / FSH, T, E2 and HOMA- (P <0.01). After treatment, the levels of LH, LH / FSH, T and HOMA-IR in the two groups were significantly lower than those in the control group (P <0.01) <0.01). There was no significant difference in FSH and E2 levels between the two groups before and after treatment (P> 0.05). Conclusions The combination of metformin and ethinyl estradiol and cyproterone in the treatment of adolescent PCOS can relieve the state of insulin resistance, decrease the levels of insulin and testosterone in blood and improve the symptoms and signs on the basis of effectively improving the menstrual cycle Reliable, worth promoting.