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目的:了解个体从业健康体检人员亚临床甲状腺功能减退症(SCH)的检出率,并观察SCH血清促甲状腺激素(TSH)与血脂的关系。方法:选取2007年个体从业健康体检人员血清2958份,采用化学免疫分析法测定TSH、游离三碘甲状腺原氨酸(FT3)和游离四碘甲状腺原氨酸(FT4)。血生化指标采用全自动生化检测仪测定。结果:2958例SCH总检出率7.03%。其中女性检出率8.95%,男性检出率4.79%,女性检出率高于男性(P<0.01)。从年龄结构看:50岁~59岁组检出率最高11.73%,其次是18岁~29岁组和60C以上岁组。TSH与血脂相关因素中,男性TSH与尿酸(UA)呈正相关,与载酯蛋白A(APOA)呈负相关。结论:我科个体从业健康体检人员SCH总检出率较上海(6.1%)、南昌地区(6.1%)高;SCH的发生与年龄和性别相关;TSH血浓度对血脂的影响因性别不同而不同。
Objective: To understand the detection rate of subclinical hypothyroidism (SCH) in individual health examination staff and to observe the relationship between SCH serum thyroid stimulating hormone (TSH) and blood lipid. Methods: A total of 2958 serum samples were collected from individual practitioners in 2007, and TSH, free triiodothyronine (FT3) and free tetraethionine (FT4) were determined by chemical immunoassay. Blood biochemical indicators using automatic biochemical detector determination. Results: The total detection rate of 2958 SCH was 7.03%. Among them, the detection rate of women was 8.95%, the detection rate of men was 4.79%, and the detection rate of women was higher than that of men (P <0.01). From the age structure: the highest detection rate of 50 years old to 59 years old group was 11.73%, followed by 18 years old to 29 years old group and over 60 years old group. TSH and blood lipid related factors, male TSH and uric acid (UA) was positively correlated with carrier protein A (APOA) was negatively correlated. Conclusions: The total detection rate of SCH was higher in individuals with physical examination in our department than those in Shanghai (6.1%) and Nanchang (6.1%); the incidence of SCH was related to age and gender; the effect of TSH blood concentration on blood lipids varied with gender .