用正交设计法研究了离子缔合物的种类、膜相中活性物浓度和增塑剂3个因素对电极性能的影响,以四苯硼-洛美沙星形成的缔合物为电活性物质研制了涂碳PVC膜洛美沙星电极.其能斯特响应范围为2.0×10~(-3)～1.0×10~(-5)mol/L;检测限为4.0×10~(-6)mol/L,级差为28.9mV/pC.该电极响应迅速,重复性和稳定性好,应用于洛美沙星药片的含量测定,方法简便,结果满意. Orthogonal design method was used to study the influence of the ion association species, the concentration of active species in the membrane phase and the plasticizer on the electrode performance. The complex formed by tetraphenyl boron-lomefloxacin was an electroactive material A carbon film coated with lomefloxacin (PVC) film was developed with a Nernst response range of 2.0 × 10 -3 to 1.0 × 10 -5 mol / L and a detection limit of 4.0 × 10 -6. mol / L, with a step difference of 28.9mV / pC.The electrode has rapid response, good repeatability and stability, and is suitable for the determination of lomefloxacin tablets. The method is simple and the results are satisfactory.