论文部分内容阅读
性别导致免疫功能的差异主要归结于激素水平和染色体两方面。不同种类和浓度的性激素对免疫功能的作用也存在着差异。体内性激素的差异能够影响疾病的易患性、治疗和预后。低浓度的雌激素能增强免疫功能,而雄激素和高浓度的雌激素均能抑制免疫功能。同时,性染色体上也存在着大量与免疫功能相关的基因,且性染色体上基因的突变和染色体数目的异常均会通过免疫功能的改变导致疾病的发生。该文就性别与免疫功能关系的研究进展予以综述。
Gender differences in immune function are mainly due to hormone levels and chromosomes. Different types and concentrations of sex hormones on the role of immune function there are differences. Sex hormone differences in the body can affect the disease’s susceptibility, treatment and prognosis. Low concentrations of estrogen can enhance immune function, and androgens and high concentrations of estrogen can inhibit immune function. At the same time, there are a large number of sex chromosomes and immune-related genes, and sex chromosome mutations and chromosomal abnormalities in the number of abnormal immune function will lead to the occurrence of the disease. This article reviews the research progress of the relationship between sex and immune function.