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用中子(积分通量1×1013)及γ射线(1×104R)照射以注射药为主的72种常用药物,在辐照后48小时测定其感生放射性,并按中华人民共和国药典及生物制品检定规程进行检定。还测定了36种药物的LD50及观察40种药物的主要药理作用,在辐照后3个月时重复检定1次。实验结果表明;在辐照后48小时仅葡萄糖氯化钠注射液及氯化钾注射液感生放射性在10-1μ水平。3个月时全部药物均在本底外水平。 有59种药物在辐照以后其外观、理化性质、含量、毒性、效价(包括类毒素等的免疫力)均与对照药物相似。有明显变化者3种。其中以维生素B12为最。在本实验的辐射剂量范围内,其含量下降与辐照剂量呈明显的负相关及线性关系。麻醉乙醚在辐照后产生了过氧化物;0.1％枸橼酸注射液含量下降均不符合规定的标准。此外尚有硫
72 kinds of commonly used drugs, mainly injections, were irradiated with neutrons (fluence 1 × 1013) and γ rays (1 × 104R), and the induced radioactivity was measured 48 hours after irradiation. According to the Pharmacopoeia of the People’s Republic of China and Biological products testing procedures for testing. Also measured the LD50 of 36 drugs and observed the main pharmacological effects of 40 drugs, 3 months after irradiation repeated test 1 time. The experimental results show that only 48h after irradiation glucose and sodium chloride injection potassium chloride injection induced radioactivity in the 10-1μ level. 3 months when all drugs are in the background outside the level. The appearance, physicochemical properties, content, toxicity, potency (including the immunity of toxoid and other toxins) of 59 drugs after irradiation were similar to the control drugs. There are three obvious changes. One of the most vitamin B12. In the experimental radiation dose range, the content decreased and radiation dose was significantly negatively correlated and linear relationship. Anesthetic ether produced peroxide after irradiation; 0.1% citrate injection did not fall in compliance with the required standard. In addition there is sulfur