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尼莫地平(1)为钙通道拮抗剂,主要用于防治缺血性脑血管疾病[1]、偏头痛、轻度蛛网膜下腔出血引起的脑血管痉挛、突发性耳聋及轻中度高血压病。其常用剂型有片剂、胶囊剂、缓释剂等。但该药为脂溶性,口服生物利用度低。我厂采用混合分散载体[2]研制出溶出速率快、生物利用?..
Nimodipine (1) is a calcium channel antagonist, mainly used for the prevention and treatment of ischemic cerebrovascular disease [1], migraine, cerebral vasospasm caused by mild subarachnoid hemorrhage, sudden deafness and mild to moderate High blood pressure. Its commonly used formulations are tablets, capsules, sustained release agents. But the drug is fat-soluble, low oral bioavailability. I plant mixed dispersed carrier [2] developed a dissolution rate, bio-utilization?