论文部分内容阅读
目的研发血液存储与输注的聚丙烯材料。方法采用预辐照(15 kGy)与反应加工相结合的方法,将2种分子量分别为300和475的聚乙二醇单甲醚甲基丙烯酸酯接枝到聚丙烯的分子链上,予以接枝产物通过红外光谱表征,接枝产物力学性能通过拉伸试验予以表征,材料的亲水性通过静态水接触角予以表征,血液相容性通过蛋白质吸附和血小板吸附予以表征。结果聚丙烯接枝产物的最低拉伸强度和断裂伸长率分别为32 MPa和780%,仅略低于纯聚丙烯材料的拉伸强度(39 Mpa)和断裂伸长率(900%)。与纯聚丙烯材料相比,接枝聚丙烯材料表面形成了亲水性膜,牛血清蛋白吸附量和血小板粘附量分别降低70%和80%,有效提高了聚丙烯材料的血液相容性。结论聚丙烯材料的表面结构经过调控,能有效提高其血液相容性,用做聚烯烃类血液存储与输注的材料。
Objective To develop a polypropylene material for blood storage and infusion. Methods Two kinds of polyethylene glycol monomethyl ether methacrylate with molecular weights of 300 and 475, respectively, were grafted onto the molecular chain of polypropylene by a combination of pre-irradiation (15 kGy) and reaction processing. The mechanical properties of the grafted product were characterized by tensile test. The hydrophilicity of the material was characterized by static water contact angle and the blood compatibility was characterized by protein adsorption and platelet adsorption. Results The lowest tensile strength and elongation at break of polypropylene grafted product were 32 MPa and 780% respectively, only slightly lower than that of pure polypropylene (39 Mpa) and elongation at break (900%). Compared with the pure polypropylene material, the surface of the graft polypropylene material formed a hydrophilic film, the amount of bovine serum albumin adsorption and platelet adhesion decreased by 70% and 80%, respectively, effectively improving the blood compatibility of the polypropylene material . Conclusion The surface structure of polypropylene material through regulation, can effectively improve the blood compatibility, used as polyolefin blood storage and infusion of materials.