一、引言克山病是一种以心肌变性病变为主的地方病。自1935年在黑龙江省克山县首次暴发该病以来,先后在我国17个省区发现本病。在过去大流行年代,急型克山病发病率高,死亡惨重,严重危害了病区人民的健康和生命。解放以后,党和政府对克山病的防治研究十分重视,建立了地方病研究所,组织多学科的专家、教授等深入病区,进行了长期的调查和实验研究,从而在克山病病因方面先后提出了多种假说或学说。概括起来可分为两大类:一是生物性病因学说,包括自然疫源学说、病毒学说和真菌毒素中毒学说等;另一是非生物性病因学 First, the introduction Keshan disease is a degeneration of myocarditis endemic disease. Since the first outbreak of the disease in Keshan County, Heilongjiang Province in 1935, it has been found in 17 provinces in China. In the past pandemic era, acute Keshan disease has a high incidence and heavy death toll, which has seriously endangered the health and lives of the ward people. After the liberation, the party and the government attached great importance to the prevention and treatment of Keshan disease, established the Institute of Endemic Diseases, organized multidisciplinary experts and professors to go deep into the ward and conducted long-term investigation and experimental research, so that in the cause of Keshan disease Has put forward a variety of hypotheses or doctrines. To sum up can be divided into two categories: First, the theory of biological etiology, including natural foci theory, viral theory and mycotoxin poisoning theory; the other is non-biological etiology