糖尿病脑病临床上以认知功能障碍为特点,与海马突触可塑性的变化密切相关,包括突触结构和功能的可塑性。结构方面表现为突触变性,突触数量、突触小泡与突触后致密物厚度减少,突触间隙宽度增加。功能方面表现为长程增强效应降低或长程抑制效应易化。 Diabetic encephalopathy is clinically characterized by cognitive dysfunction and is closely related to changes in synaptic plasticity in the hippocampus, including synaptic structure and functional plasticity. The structural aspects of the performance of the synaptic degeneration, the number of synapses, synaptic vesicles and postsynaptic density of the thickness decreased, the width of the synaptic cleft increased. Functional aspects of the performance of long-term enhancement effect or long-term inhibition of the effect of facilitation.