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本文应用放射免疫法测定吲哚美辛 IUD对离体大鼠子宫匀浆中前列腺素类物质(PGs)释放的影响 ,用光镜和电镜观察放置吲哚美辛 IUD后大鼠子宫内膜的形态学变化 ,并测定吲哚美辛 IUD在大鼠子宫内的动态释放规律。结果表明 :吲哚美辛组 PGs释放约为铜组的 1 / 5～ 1 / 1 0 (P<0 .0 5 ) ,而且吲哚美辛抑制 PGs释放的作用随药物浓度增加而增强。铜组和硅橡胶组 PGs释放均有随时间累积而增加趋势 ,而吲哚美辛组无此表现。 6KF和 TXB2 的比值 ,吲哚美辛组和硅橡胶组均 <1 (0 .6～ 0 .8) ,而铜组则均 >1 (1 .3～ 2 .1 )。组织学观察 ,铜 IUD组可见子宫内膜组织充血水肿 ,微血管以扩张为主 ,吲哚美辛 IUD组则无充血水肿表现 ,微血管以正常和收缩状态为主。吲哚美辛 IUD在大鼠子宫内药物释放量 3 d后稳定 ,释放速度稳定递减 ,符合均质型缓释规律。
In this paper, radioimmunoassay was used to determine the effect of indomethacin IUD on the release of prostaglandins (PGs) in isolated rat uterine homogenates. The endometrial contents of indomethacin IUD Morphological changes, and determination of indomethacin IUD dynamic release patterns in rat uterus. The results showed that the release of PGs in indomethacin group was about 1/5 ~ 1/10 (P <0.05) of copper group, and the effect of indomethacin inhibiting PGs release increased with increasing concentration of PGs. The release of PGs in the copper group and the silicone rubber group both increased with time, while the indomethacin group did not. The ratios of 6KF to TXB2 were both indomethacin group and silicone rubber group <1.0 (0.6 ~ 0.8), while those of copper group were all> 1 (1.3-2.1). Histological observation, copper IUD group showed endometrial congestion and edema, mainly to expand the microvascular, indomethacin IUD group was no congestion and edema, microvascular to normal and contracted state. Indomethacin IUD in rat uterine drug release 3d after the steady release rate steady decline, in line with the law of homogeneous slow release.