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目的：评价国产氟西汀对抑郁症的疗效及安全性。方法：用国产氟西汀和阿米替林随机双盲对照治疗严重抑郁障碍病人共１６例。氟西汀组８例（男性４例，女性４例，年龄５１±ｓ１５ａ），口服氟西汀２０ｍｇ，ｑｄ；阿米替林组８例（男性３例，女性５例，年龄５１±１６ａ），口服阿米替林７５ｍｇ，ｂｉｄ。疗程６ｗｋ。结果：２组病人治疗后ＨＡＭＤ，ＨＡＭＡ，ＳＤＳ评分均显著下降，但２组间比较无显著差异。２组病人的显效率均为７５％。治疗后ｗｋ１，２，６末ＴＥＳＳ评分值氟西汀组均低于阿米替林组。结论：国产氟西汀疗效同阿米替林相当，但副作用较轻微。
Objective: To evaluate the efficacy and safety of domestic fluoxetine in the treatment of depression. Methods: A total of 16 patients with severe depressive disorder were treated with double-blind randomized controlled trials of domestic fluoxetine and amitriptyline. Fluoxetine group 8 cases (4 males, 4 females, age 51 ± s15a), oral fluoxetine 20mg, qd; amitriptyline group of 8 patients (3 males and 5 females, age 51 ± 16a) , Oral amitriptyline 75mg, bid. Treatment 6wk. Results: After treatment, the scores of HAMD, HAMA and SDS decreased significantly in both groups, but there was no significant difference between the two groups. Two groups of patients were markedly effective rate of 75%. After treatment wk1,2,6 TESS score fluoxetine group were lower than amitriptyline group. Conclusion: The efficacy of domestic fluoxetine is equivalent to that of amitriptyline, but the side effects are slight.