在医药领域,病原菌的抗药性现象是人们所熟知的,早在磺胺类药物普及后不久的1940年就出现了。昆虫的抗药性问题,是从1950年左右,也就是六六六,DDT 等杀虫剂使用几年之后开始的。而植物病原菌的抗药性,真正成为问题,则只是最近十多年的事情。六十年代以前所使用的杀菌剂,如汞制剂、铜制剂、二硫化氨基甲酸盐类等都属于非选择性杀菌剂。这些药剂尽管使用了多年,但是很少出现抗药性问题。六十年代以后,一些高效的具有选择性的杀菌剂陆续在 In the field of medicine, the resistance of pathogens is well known, as early as 1940, soon after the spread of sulfonamides. The problem of insecticide resistance started some years after 1950 when pesticides such as DDT and DDT were used. The resistance of plant pathogens really become a problem, it is only the last ten years. Fungicides used until the 1960s, such as mercury preparations, copper preparations, carbamate disulfides, etc., are non-selective bactericides. Although these agents have been used for many years, there are few problems with drug resistance. Since the 1960s, some highly effective and selective bactericides have been released