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目的观察右美托咪定在重症加强护理病房(ICU)重型颅脑损伤患者镇静中的临床效果。方法 60例重型颅脑损伤患者,随机分为观察组和对照组,每组30例。对照组患者给予地西泮(商品名:安定)镇静治疗,观察组给予右美托咪定镇静治疗。比较两组患者的镇定效果。结果用药前,两组患者镇静评分、心率、血压及呼吸频率比较差异均无统计学有意义(P>0.05);用药后,两组患者的镇静评分均有所改善,且观察组患者用药后的镇静评分(2.83±0.39)分优于对照组的(1.79±0.58)分,差异有统计学意义(P<0.05)。用药后,两组患者的心率、血压及呼吸频率均有所改善,且观察组心率、血压及呼吸频率改善效果明显优于对照组,差异具有统计学意义(P<0.05)。结论在ICU重型颅脑损伤患者镇静中使用右美托咪定具有较好的效果,值得在临床中借鉴并推广。
Objective To observe the clinical effect of dexmedetomidine in the sedation of patients with severe craniocerebral injury in critical intensive care unit (ICU). Methods Sixty patients with severe traumatic brain injury were randomly divided into observation group and control group, 30 cases in each group. Patients in the control group were given diazepam (trade name: Diazepam) for sedation, while those in the observation group were given dexmedetomidine for sedation. The effects of the two groups were compared. Results Before treatment, the sedation scores, heart rate, blood pressure and respiration rate were not significantly different between the two groups (P> 0.05). After treatment, the sedation scores of both groups were improved, and the observation group patients after treatment The sedation score (2.83 ± 0.39) was better than that of the control group (1.79 ± 0.58), the difference was statistically significant (P <0.05). Heart rate, blood pressure and respiratory rate were improved in both groups after treatment, and the improvement of heart rate, blood pressure and respiratory rate in the observation group was significantly better than that in the control group (P <0.05). Conclusions The use of dexmedetomidine in the sedation of ICU patients with severe traumatic brain injury has a good effect, which is worth to be used in clinical practice.