乙酰螺旋霉素是大环内脂类抗生素,为白色粉末,微溶于水,溶于醇、氯仿和苯等溶剂中~([2])。本品用淀粉、糖粉、糊精为辅料制片时,当淀粉用量占片重的35%以上时,无论配比如何,不同工艺操作,其崩解度均达不到要求,但如果淀粉用量占片重的35%以下时,增加糖粉,仍难以保证片剂质量。由于羧甲基淀粉钠具有良好的吸水性和吸水膨胀性,遇水充分膨胀后,使体积增大200 Acetylspiramycin is macrolide antibiotics, white powder, slightly soluble in water, soluble in alcohol, chloroform and benzene solvent ~ ([2]). When starch, sugar powder and dextrin are used as excipients, when the amount of starch accounts for more than 35% of the tablet weight, the disintegration degree of the product will not meet the requirements regardless of the ratio and operation. However, if the starch Tablet dosage accounted for 35% of the following, the increase in sugar, it is still difficult to guarantee the quality of tablets. As sodium carboxymethyl starch has good water absorption and water swelling, with water fully expanded, so that the volume increased 200