甲基多巴(methyldopa)作用于延脑血管中枢抑制交感性血管收缩而起降血压作用。降压过程中伴有心率减慢,心输出量减少,体循环阻力下降,血浆容量增加、不影响肾血流量和肾小球滤过率。适用于肾功能不全的高血压患者,但易致钠和水的排出量受阻。我们在治疗高血压患者中应用此药,均于单独首次使用后,有2例发生少尿症,现报告如下。 Methyldopa acts on the vasomotor center and suppresses the sympathetic vasoconstriction and thus plays a role in lowering blood pressure. Decompression associated with heart rate slowed down, decreased cardiac output, decreased systemic resistance, increased plasma volume, does not affect the renal blood flow and glomerular filtration rate. For hypertensive patients with renal insufficiency, but easily lead to sodium and water discharge blocked. We are in the treatment of hypertensive patients with this drug, were used in the first single, there are 2 cases of oliguria, are as follows.