多药耐药性细菌的传播增加受到广泛关注,并因缺乏可对抗的新型抗生素而加剧。Redinbo等提出,双膦酸盐类药物可通过抑制细菌DNA释放酶,破坏细菌间抗药基因的传递,这可能是一种选择性靶向作用于可传递抗生素耐药性的多药耐药性菌株的有效新方法。研究者用X射线衍射晶体分析法确定 The increasing spread of multidrug-resistant bacteria has received widespread attention and is exacerbated by the lack of new antibiotics that can be antagonized. Redinbo et al. Suggest that bisphosphonates may disrupt the transmission of drug-resistant genes between bacteria by inhibiting bacterial DNA-releasing enzymes, which may be a selective target for multidrug resistance that can deliver antibiotic resistance An Effective New Method for Strains. The researchers determined by X-ray crystallography