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用双抗体夹心ELISA法检测了48例肾综合征出血热（HFRS）患者165份系列血清干扰素—α（IFN—α）的动态变化。结果发现，HFRS患者病程早期（发热期，第5病日前）IFN－α含量明星升高．较正常对照均有明显差异（P＜0.005），中型较轻型，危重型及重型较中型明显升高（P＜0．05）；中、重型低血压期达高峰，危重型低血压期下降；提示：HFRS患者病程早期的高滴度IFN—α有利于机体清除病毒，控制病情进展，动态检测可一定程度判定患者的预后和转归，早期补充适量的IFN—α对疾病的恢复有一定作用。
The dynamic changes of 165 serum interferon-α (IFN-α) in 48 patients with hemorrhagic fever with renal syndrome (HFRS) were detected by double antibody sandwich ELISA. The results showed that patients with early HFRS (fever period, the first day of the fifth day) IFN-α content increased. (P <0.005), moderate type, severe type and severe type were significantly higher than those of middle type (P <0.05), peaked in middle and severe hypotension, and decreased in severe type hypotension. Hint: Early high titer of IFN-α in the course of HFRS patients is good for the body to clear the virus and control the progress of the disease. The dynamic detection can determine the prognosis and prognosis of the patients to a certain extent. Early replenishment of IFN-α has a certain effect on the recovery of the disease .