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目的 研究食管粘膜下鳞癌的生物学特性。方法 通过随访及SP免疫组化技术P53 蛋白在 3 0例食管粘膜下鳞癌的表达 ,研究其生物学特性。结果 3 0例食管粘膜下鳞癌的P53 蛋白阳性表达率为 66.7% ,经病理证实术时淋巴结的转移率为 60 % ,术后各种转移率为 47.8% ,其中伴肺转移 4例 ,单纯肺转移 1例 ,其 1、2、3、4年生存率分别为 10 0 %、70 .0 %、3 1.3 %和 11.1%。结论 食管粘膜下鳞癌术时及术后转移率较高 ,术后肺转移率较高 ,P53 蛋白阳性表达率高 ,予后差。鳞化伴异型增生的食管腺上皮细胞的阳性表达提示食管粘膜下鳞癌可能发生于食管腺。
Objective To study the biological characteristics of submucosal squamous cell carcinoma of the esophagus. Methods The expression of P53 protein in 30 cases of esophageal submucosal squamous cell carcinoma was studied by follow-up and SP immunohistochemical technique to study its biological characteristics. Results The positive expression rate of P53 protein in 30 cases of esophageal submucosal squamous cell carcinoma was 66.7%. The lymph node metastasis rate was 60% after pathological examination. The postoperative metastasis rate was 47.8%, including 4 cases with pulmonary metastases. In 1 patient with lung metastases, the 1-, 2-, 3-, and 4-year survival rates were 100%, 70.0%, 31.3%, and 11.1%, respectively. Conclusions The metastasis rate of esophageal submucosal squamous carcinoma during operation and postoperative is higher, postoperative lung metastasis rate is higher, and the positive expression rate of P53 protein is high. The positive expression of esophageal glandular epithelial cells with scaled dysplasia suggests that esophageal submucosal squamous cell carcinoma may occur in esophageal glands.