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铜-64(半衰期12.7小时)是PET上常用的一种正电子放射性核素,其不仅能够作为示踪剂同时还能够用于治疗,特别是对癌症的放射治疗,效果显著。以往~(64)Cu只有通过核研究反应堆快速中子通量捕获才能生产(即质子流轰击锌),反应周期长且成本高,极大的限制了~(64)Cu的生产和应用。为实现~(64)Cu的大量生产、应用同时节约成本,国际上已开展医用回旋加速器~(64)Cu的高效制备研究,目前最常使用的是64Ni经质子束流轰击后发生核反应产生~(64)Cu。通过结合我中心实际操作经验,本文旨在阐述医用回旋加速器(能量16.5Me V)高效制备~(64)Cu的方法。以天然镍粉为电镀原材料。将其电镀成功后,利用30微安的质子束流开始轰靶,最后通过离子交换柱将~(64)Cu、64Ni和其他放射性产物快速分离,从而得到纯度高、放射性活度高的~(64)Cu。
Copper-64 (half-life 12.7 hours) is a positron-emitting radionuclide commonly used in PET that can not only be used as a tracer but also can be used for treatment, especially for radiotherapy of cancer. In the past, ~ (64) Cu was only produced by rapid neutron flux capture by nuclear research reactors (ie proton flow bombardment of zinc), long reaction period and high cost, greatly limiting the production and application of ~ (64) Cu. In order to achieve the mass production of ~ (64) Cu, the application of simultaneous cost saving has been carried out to study the efficient preparation of the medical cyclotron ~ (64) Cu in the world. At present, the most commonly used reaction is 64Ni nuclear reaction after proton beam bombardment ~ (64) Cu. By combining the practical experience of our center, this article aims to demonstrate the efficient preparation of ~ (64) Cu by medical cyclotron (energy 16.5 MeV). Natural nickel powder plating raw materials. After the plating was successful, the target was started with a proton beam flux of 30 microamperes, and the ~ (64) Cu, 64Ni and other radioactive products were quickly separated by ion exchange column to obtain high purity and high radioactivity 64) Cu.