庆大霉素肾毒性所致的少尿型急性肾功能衰竭早已引起人们的重视,但对非少尿型急性肾功能衰竭(NOARF)常被忽视,我科遇到2例,现予报道。 1 临床资料【例1】女,24岁。因患风湿性心脏病、主动脉瓣闭锁不全,于1987年4月25日在体外循环低温麻醉下行主动脉瓣及二尖瓣(机械瓣)置换术。术前尿蛋白(+),血清尿素氮(BUN)3.28mmol/L。术后给予庆大霉素24万u/d及氨基苄青霉 Gentamicin nephrotoxicity caused by oliguria acute renal failure has drawn people’s attention, but non-oliguric acute renal failure (NOARF) are often overlooked, our department encountered two cases are reported. 1 clinical data [Example 1] Female, 24 years old. Due to rheumatic heart disease, aortic valve atresia, in April 25, 1987 underwent hypothermic cardiopulmonary bypass with aortic valve and mitral valve (mechanical valve) replacement. Preoperative urine protein (+), serum urea nitrogen (BUN) 3.28mmol / L. After gentamicin 240,000 u / d and ampicillin