胆道闭锁Kasai手术后胆管炎病因的研究进展

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胆道闭锁Kasai术后胆管炎影响了患儿自体肝的生存状况,尤其是Kasai术后1年内反复发生的胆管炎,更易形成难治性胆管炎,严重影响了胆道闭锁Kasai手术的治疗效果。目前Kasai术后胆管炎病因尚不清楚,多数学者认为并非单一因素所致,与胆汁引流量下降、术后类固醇激素使用、肠道菌群移位、自身免疫损伤等因素密切相关。本文综述了胆道闭锁Kasai术后胆管炎发生的相关因素,为将来胆道闭锁的进一步治疗及Kasai术后胆管炎并发症的防治提供参考。“,”Cholangitis of biliary atresia (BA) after Kasai procedure (KP) affects the survival status of native liver in children. Especially cholangitis recurring within 1 year post-KP is more likely to become refractory. The etiology of BA has remained elusive. Most scholars believe that it is not caused by a single factor, but closely correlated with such factors as reduced bile drainage, postoperative steroid hormone use, intestinal flora shift and autoimmune damage. Reviewing the relevant factors of cholangitis of BA post-KP, this review provided a reference for future treatment of BA and prevention and management of cholangitis complications post-KP.
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