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目的探讨我院抗菌药相关性腹泻((Antibacterial associated diarhea,AAD)的发生、预防及治疗。方法回顾分析我院内科2009年5月1日至2010年5月1日发生AAD的临床资料。查询病例均在使用抗生素期间或之后出现腹泻,以老年患者、儿科患者、肝肾功能异常患者为主;发生AAD的抗生素中常见致病药物包括:头孢哌酮/舒巴坦、头孢克洛、克林霉素、阿奇霉素、红霉素等,均为静脉滴注给药;北京306医院儿科郑成中无抗菌药相关性腹泻的死亡病例。结论医师临床应用抗菌药物时,应合理选择使用抗生素,加强对患者监测,尽量减少长时间大量的使用抗生素,同时使用口服微生态制剂和止泻药等预防AAD的发生。
Objective To investigate the occurrence, prevention and treatment of anti-bacterial associated diarhea (AAD) in our hospital.Methods The clinical data of AAD in our department from May 1, 2009 to May 1, 2010 were retrospectively analyzed. Diarrhea occurred during or after the use of antibiotics in elderly patients, pediatric patients and patients with liver and kidney dysfunction. The common pathogenic drugs in antibiotics with AAD include cefoperazone / sulbactam, cefaclor, Lincomycin, azithromycin, erythromycin, etc., are administered intravenously; Beijing 306 Hospital Pediatric Cheng Chengzhong no antibacterial drug-related diarrhea deaths .Conclusion The clinical use of antibiotics, physicians should choose the appropriate use of antibiotics to enhance the Patient monitoring minimizes prolonged use of antibiotics, while using oral probiotics and antidiarrheal agents to prevent AAD.