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良性前列腺增生症(benign prostatic hyperplasia,BPH)是中老年男性排尿障碍原因中最常见的良性疾病~([1,2])。近年来越来越多的研究表明,雌激素可能参与了前列腺腺体的自稳调节和间质增生的形成,由于雌激素主要通过雌激素受体(ER)发挥生物学功能,因此,雌激素及其受体在其发病中的作用机制越来越受到重视。本文对雌激素及ER与BPH的相关性研究做一综述。
Benign prostatic hyperplasia (BPH) is the most common benign disease in the causes of voiding dysfunction in middle-aged and elderly men (1,2). In recent years, more and more studies have shown that estrogen may be involved in the regulation of prostatic glands and the formation of interstitial hyperplasia. Because estrogen exerts biological functions mainly through the estrogen receptor (ER), estrogen And its receptor in the pathogenesis of its role in more and more attention. This article reviews the relationship between estrogen and ER and BPH.