引言迄今为止,关于氚标记雌三醇的制备方法可以归纳如下两种:1.直接化学合成法,该法应用氚-卤催化取代、还原等化学反应来制备定位的氚标记雌二醇。如雌三醇-2,4-T,雌三醇-17α-T等;2.催化交换法。在催化剂存在的条件下,直接以被标记物为原料在氚气氛中进行交换反应,便可以制取雌三醇-T(G)。在不需要定位标记时, INTRODUCTION Up to now, there are two methods for the preparation of tritium-labeled estriol: 1. Direct chemical synthesis, which uses the tritium-halogen catalyzed substitution and reduction chemical reactions to prepare the targeted tritiated estradiol. Such as estriol-2,4-T, estriol-17α-T, etc .; 2 catalytic exchange method. In the presence of a catalyst, estriol-T (G) can be prepared by directly exchanging the labeled material in a tritium atmosphere. When you do not need positioning markers,