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尽管以顺铂为基础的联合化疗对卵巢癌的首次治疗有效率提高,但是多数卵巢癌死于肿瘤对药物的耐药性。这种耐药性在较早使用大剂量化疗加自体骨髓移植治疗白血病及淋巴瘤中已被克服。通过这种方法治疗30例复发或难治性上皮性卵巢癌,前瞻性研究了其临床意义和危险因素。 本实验组共30例病例,均为首次减瘤术后给予1～4次以顺铂为基础的联合化疗的复发性上皮性卵巢癌,其中20例对铂类药物耐药(占67％),其余10例对铂类药物敏感(占33％),22例病例肿瘤直
Although cisplatin-based combination chemotherapy is an effective first-line treatment for ovarian cancer, most ovarian cancers die of tumor drug resistance. This resistance has been overcome by earlier use of high-dose chemotherapy plus autologous bone marrow transplantation in the treatment of leukemias and lymphomas. By this method of treatment of 30 cases of recurrent or refractory epithelial ovarian cancer, prospective study of its clinical significance and risk factors. The experimental group a total of 30 cases, were the first time after surgery to give 1 to 4 cisplatin-based chemotherapy combined with recurrent epithelial ovarian cancer, including 20 cases of platinum-resistant (67%) , The remaining 10 cases were sensitive to platinum drugs (33%), 22 cases of tumor straight