制备了一种能在胃内漂浮12 h并在期间缓慢释出90%药物的盐酸雷尼替丁漂浮片,有利于该药在较窄部位的吸收和改善其在结肠环境降解的问题。采用FT-IR和DSC方法进行相容性研究,筛选所需辅料。以片剂硬度、药物释放、药物释放动力学、起漂时间和总漂浮时间为指标,进行初步筛选。结果表明,Klucel-LF、POLYOX WSR N 60 K和1-薄荷醇分别适合作为漂浮片的黏合剂、聚合物和升华剂。再以聚合物和升华材料为自 A ranitidine hydrochloride floating tablet that floated in the stomach for 12 h and slowly released 90% of the drug during the period was prepared to facilitate absorption of the drug at narrower sites and to improve its degradation in the colon environment. Using FT-IR and DSC methods for compatibility studies, screening of the necessary accessories. The initial screening was carried out with tablet hardness, drug release, drug release kinetics, bleaching time and total floating time as indexes. The results show that Klucel-LF, POLYOX WSR N 60 K and 1-menthol are suitable as binders, polymers and sublimation agents for floating tablets, respectively. Then polymer and sublimation materials for self