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1 Genetic disease Genetic disease is one of the top classes of human diseases.Several thousand types of human genetic diseases have been identified.Most of the family may contain genetic disorders,and at least 10 percent of all adults contain genetic defects (http://www.britannica.com/EBchecked/topic/228874/human-geneticdisease) [1].In China,over 1 million new born babies have genetic birth deficiency annually (http://www.dcmst.org.cn/bencandy.php? fid =14&id =273 ).While the individuals with genetic diseases passed away before reaching the reproduction age will eliminate the diseases from the human population,the individuals reaching the reproduction age will transmit the diseases to the new generation,therefore,the diseases will remain in the human population.China has the largest human population in the world and Shandong is one of the most populated provinces in China.In the foreseeable future,most of the genetic diseases will not be curable.