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作者研究了不同剂量的阿斯匹林和潘生丁(Dipyridamole)对健康志愿者的血小板功能和出血时间的作用。每隔2周使用阿斯匹林,剂量在60mg至1g之间。2小时后测试血小板功能和出血时间,观察到使用300mg时血小板功能的抑制最大,出血时间延长。使用1g时出血时间进一步延长。作者在同一志愿者身上使用2.1,3和3.9g剂量进行反复观察,证实出血时间的一个反常作用。使用剂量不超过1g时,出血时间逐渐延长,而当剂量较大时出血时间又恢复正常,如表所示:
The authors studied the effects of different doses of aspirin and dipyridamole on platelet function and bleeding time in healthy volunteers. Use aspirin every 2 weeks at doses between 60mg and 1g. After 2 hours, the platelet function and bleeding time were tested. When 300 mg was used, the inhibition of platelet function was maximal and the bleeding time was prolonged. Use 1g when the bleeding time to further extend. The authors repeated observations on the same volunteer at doses of 2.1, 3 and 3.9 g, confirming an anomalous effect of bleeding time. The use of dose does not exceed 1g, the bleeding time gradually extended, and when the dose is large bleeding time returned to normal, as shown in the table: