毒扁豆碱是乙酰胆碱酯酶抑制剂,槟榔碱是毒蕈碱增效剂。两者肠道外用药能改善一些老年前型阿尔茨海默病的痴呆状况,但口服用药,由于首过效应而变得无效。经鼻腔用药能避免这种首过效应,从而提高药物的生物利用度,为毒扁豆碱、槟榔碱的应用提供了一种可供选择的途径。为分析两种药物经鼻给药的生物利用度及吸收情况,用Lewis鼠进行了实验研究。 Physostigmine is an acetylcholinesterase inhibitor and arecoline is a muscarinic synergist. Both of these parenteral drugs can improve dementia in some presenile Alzheimer’s disease, but oral medication becomes ineffective due to the first pass effect. Nasal medication to avoid this first pass effect, thereby enhancing the bioavailability of drugs for the use of physostigmine, arecoline provides an alternative route. In order to analyze the bioavailability and absorption of nasal administration of two drugs, Lewis rats were used in the experiment.