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由于药物的溶解速度对消化道的吸收有很大影响,所以加快难溶性药物的溶解速度的方法,如微粉化法,共沉淀法、混合粉碎法等的报告很多。认为难溶性药物和高分子化合物混合粉碎可使药物非晶质化而改善溶解性能,非晶质化程度可因添加物的种类和混合的比例不同而异,药物和添加物的物理化学的相互作用对溶解性和吸收性的影响很大。消炎镇痛剂α-oxo-3[4-(1-Oxo-2-异吲哚满
As drug dissolution rate has a great influence on the absorption of digestive tract, there are many reports of methods to speed up the dissolution rate of insoluble drugs, such as micronization, coprecipitation, and mixed crushing. It is considered that the mixing and pulverizing of a poorly-soluble drug and a polymer compound can make the drug amorphous and improve the dissolvability. The degree of amorphization varies depending on the kind of the additive and the ratio of the mixture, and the physico-chemical interaction between the drug and the additive Effect on the solubility and absorption of great influence. Anti-inflammatory analgesic α-oxo-3 [4- (1-Oxo-2-isoindoline