论文部分内容阅读
目的:观察眼部离子导入激素配合丹栀逍遥散内服治疗青少年急性视神经炎的临床疗效。方法:选择青少年急性视神经炎患者38例(44眼),随机分为对照组20眼和治疗组24眼。对照组采用大剂量甲基强的松龙冲击疗法,静脉滴注;治疗组采用眼部直流电离子导入甲基强的松龙配合丹栀逍遥散加减。观察治疗前后视力、裂隙灯、眼底、图像视觉诱发电位(P-VEP)、电脑视野(视力允许患者行此项检查)检查结果变化,并进行激素副作用观察。结果:总有效率治疗组为83.3%,对照组为60.0%,2组总有效率比较,差异有显著性意义(P<0.05)。2组治疗前及对照组治疗前后最佳矫正视力分布情况比较,差异均无显著性意义(P>0.05);治疗组治疗前后比较,差异有显著性意义(P<0.05)。2组治疗前P-VEP检查振幅及潜伏期比较,差异均无显著性意义(P>0.05),2组治疗1月、6月后P-VEP检查振幅及潜伏期比较,差异均有显著性意义(P<0.05),提示治疗组明显优于对照组。治疗组副作用明显少于对照组。结论:应用眼部离子导入激素配合丹栀逍遥散内服治疗青少年急性视神经炎,治疗效果良好,能减轻全身激素应用的副作用,是值得推广的治疗方法。
Objective: To observe the clinical efficacy of intraocular iontophoresis combined with Danzhixiaoyao powder in the treatment of acute optic neuritis in adolescents. Methods: Thirty-eight patients (44 eyes) with juvenile acute optic neuritis were randomly divided into control group (20 eyes) and treatment group (24 eyes). The control group was treated with high dose methylprednisolone impact therapy and intravenous drip. In the treatment group, methylprednisolone was introduced into the treatment group with Danzhixiaoyao San addition and subtraction. Visual acuity, slit lamp, fundus, image visual evoked potentials (P-VEP), computer vision (eyesight allows the patient to do this test) examination results before and after treatment, and observe the hormonal side effects. Results: The total effective rate was 83.3% in the treatment group and 60.0% in the control group. The total effective rate in the two groups was significantly different (P <0.05). There was no significant difference in the best corrected visual acuity before and after treatment between the two groups before and after treatment (P> 0.05). There was significant difference between the two groups before and after treatment (P <0.05). There was no significant difference in amplitude and latency of P-VEP between the two groups before treatment (P> 0.05). The amplitude and latency of P-VEP in both groups after treatment for 1 month and 6 months were significantly different P <0.05), suggesting that the treatment group was significantly better than the control group. The side effects in the treatment group were significantly less than those in the control group. CONCLUSION: It is worth to popularize the treatment that the eye iontophoretic hormone combined with Danzhixiaoyao powder for the treatment of acute optic neuritis in adolescents with good therapeutic effect and can reduce the side effects of systemic hormones.