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目的:观察泰索帝联合顺铂治疗晚期乳腺癌临床疗效及毒副作用。方法:晚期乳腺癌53例,治疗组17例:泰索帝30 mg/m2～40 mg/m2,第1天,第8天,第15天,顺铂40 mg,第1天～第3天,28 d为1周期,连用2周期～4周期;对照组36例:CTX600 mg/m2,ADM40 mg/m2,PDD40 mg第1天～第3天,3周～4周为1周期,连用2周期～4周期。结果:治疗组17例,CR3例,PR10例,NC3例,PD1例,有效率76.5 %;对照组36例,CR2例,PR17例,NC12例,PD5例,有效率52.8 %(P<0.05)。泰索帝组化疗毒副作用,主要是骨髓抑制,白细胞减少,腹泻、变态反应、支气管哮喘、脱发、外周神经炎。结论:以泰索帝+顺铂治疗晚期乳腺癌的疗效肯定,并优于CTX+ADM+PDD方案,毒副作用小,耐受性好。
Objective: To observe the clinical efficacy and side effects of taxotere combined with cisplatin in the treatment of advanced breast cancer. Methods: 53 cases of advanced breast cancer, 17 cases of treatment group: Taxotere 30 mg / m2 ~ 40 mg / m2, the first day, the eighth day, the first 15 days, cisplatin 40 mg, the first day to the third day , 28 d for 1 cycle, once every 2 cycles to 4 cycles; control group of 36 patients: CTX600 mg / m2, ADM40 mg / m2, PDD40 mg day 1 to day 3, 3 weeks to 4 weeks for 1 cycle, Period ~ 4 cycles. Results: The treatment group of 17 cases, CR3 cases, PR10 cases, NC3 cases, PD1 cases, the effective rate was 76.5%; control group 36 cases, CR2 cases, PR17 cases, NC12 cases, PD5 cases, the effective rate was 52.8% . Taxotere group chemotherapy side effects, mainly myelosuppression, leukopenia, diarrhea, allergies, bronchial asthma, hair loss, peripheral neuritis. Conclusion: The efficacy of Taxotere + Cisplatin in the treatment of advanced breast cancer is higher than that of CTX + ADM + PDD. The toxicity and side effects are small and well tolerated.