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Oxidative stress may contribute to the pathogenesis of amyotrophic lateral sc lerosis (ALS). We therefore examined prospectively whether individuals who regul arly use supplements of the antioxidant vitamins E and C have a lower risk of AL S than nonusers. The study population comprised 957,740 individuals 30 years of age or older participating in the American Cancer Society s Cancer Prevention Study II. Information on vitamin use was collected at time of recruitment in 198 2; participants then were followed up for ALS deaths from 1989 through 1998 via linkage with the National Death Index. During the follow up, we documented 525 deaths from ALS. Regular use of vitamin E supplements was associated with a low er risk of dying of ALS. The age and smoking adjusted retlaive risk was 0.9 9 (95% confidence interval [CI], 0.69- 1.41) among occasional users, 0.59 (95 % CI, 0.36- 0.96) in regular users for less than 10 years, and 0.38 (95% CI , 0.16- 0.92) in regular users for 10 years or more as compared with nonusers o f vitamin E (p for trend = 0.004). In contrast, no significant associations were found for use of vitamin C or multivitamins. These results suggest that vitamin E supplementation could have a role in ALS prevention.
Oxidative stress may contribute to the pathogenesis of amyotrophic lateral sc lerosis (ALS). We hereby examined prospectively whether individuals who regul arly use supplements of the antioxidant vitamins E and C have a lower risk of AL S than nonusers. The study population 957,740 30 years of age or older participating in the American Cancer Society’s Cancer Prevention Study II. Information on vitamin use was collected at time of recruitment in 198 2; participants then were followed up for ALS deaths from 1989 through 1998 via linkage with the National Death index from ALS. Regular use of vitamin E supplements was associated with a low er risk of dying of ALS. The age and smokingadged retlaive risk was 0.9 9 (95% confidence in occasions users, 0.59 (95% CI, 0.36- 0.96) in regular users for less than 10 years, and 0.38 (95% CI, 0.16- 0.92) in regular users for 10 ye ars or more as compared with nonusers o f vitamin E (p for trend = 0.004). In contrast, no significant associations were found for use of vitamin C or multivitamins. These results suggest that vitamin E supplementation could have a role in ALS prevention.