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大量胆固醇在动脉壁内堆积是动脉粥样硬化病变的主要化学特性,也是粥样斑块发生发展过程中的重要环节。病变中堆积的这些胆固醇绝大部分来源于血浆。但血浆中胆固醇进入动脉壁的机理,尚未得到最后阐明。近年有些研究工作说明,动脉内膜损伤可能是使血浆脂质得以进入动脉壁的主要因素。高胆固醇血症本身可否损伤动脉内膜,仍不清楚。国外有些研究工作测定了主动脉组织呼吸的变化,但其结果颇不一致。为此,我们观察了实验性动脉粥样硬化过程中主动脉组织耗氧量的变化,又测定静脉注射高脂血清对正常家兔主动脉组织耗氧量的影响。现将实验结果报告如下。
Accumulation of large amounts of cholesterol in the arterial wall accumulation of atherosclerotic lesions of the main chemical properties, but also the development of atherosclerotic plaque in the development of an important part. The vast majority of these cholesterol deposits in the lesion come from plasma. However, the mechanism of plasma cholesterol entering the arterial wall has not yet been finally elucidated. In recent years, some studies have shown that arterial intimal injury may be the main factor in the plasma lipid into the artery wall. Hypercholesterolemia itself can damage the intima, is still not clear. Some foreign research measured changes in aortic tissue respiration, but the results are quite inconsistent. To this end, we observed changes in aortic tissue oxygen consumption during experimental atherosclerosis and determined the effect of intravenous hyperlipidemia on oxygen consumption in normal aorta tissue. The experimental results are reported below.