脓毒症微循环障碍的红细胞流变性改变

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脓毒症是一个复杂的病理生理过程,涉及微循环、血液主要成分的生理生化改变.红细胞流变性的恶化可损害微循环和组织氧供需平衡,进而导致多器官功能衰竭和死亡.红细胞的流变性受多因素影响,包括细胞内的Ca2+浓度、ATP、2,3-二磷酸甘油酸水平的改变、一氧化氮和温度的作用以及白细胞的相互影响等.现主要就脓毒症的红细胞流变性改变和可能的影响机制予以综述.
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