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目的探讨不同剂量孕激素治疗无排卵型月经失调的临床效果。方法回顾性分析2015年8月至2016年12月无排卵型月经失调患者资料89例,按照就诊顺序随机分为A组(23例)、B组(22例)、C组(22例)、D组(22例),均采用孕激素治疗,A组每日给予100 mg,B组每日给予200 mg,C组每日给予300 mg,D组每日给予400 mg,比较4组患者的临床治疗效果、阴道出血情况及不良反应。结果 4组患者治疗后总有效率比较,差异无统计学意义(P>0.05);4组患者治疗后阴道出血率、出血时间、出血量评分差异均无统计学意义(均P>0.05);4组患者治疗前后子宫内膜厚度差异均无统计学意义(均P>0.05);A、B、C、D组患者治疗过程中不良反应发生率分别为4.3%、9.1%、18.2%、27.3%,差异有统计学意义(P<0.05)。结论不同剂量孕激素治疗无排卵型月经失调均可获得良好的疗效,但低剂量孕激素产生的不良反应较少,应用价值更高。
Objective To investigate the clinical effects of different doses of progesterone on anovulatory menstrual disorders. Methods A total of 89 patients with anovulatory dysmenorrhea from August 2015 to December 2016 were retrospectively analyzed. They were randomly divided into group A (n = 23), group B (n = 22), group C (n = 22) Group D (n = 22) were treated with progestin. Group A received 100 mg daily, Group B received 200 mg daily, Group C received 300 mg daily, Group D received 400 mg daily, compared with Group 4 Clinical effect, vaginal bleeding and adverse reactions. Results There was no significant difference in the total effective rate after treatment between the 4 groups (P> 0.05). There was no significant difference in the rates of bleeding, bleeding time and bleeding between the 4 groups after treatment (all P> 0.05). There was no significant difference in the endometrial thickness between the 4 groups before and after treatment (all P> 0.05). The incidences of adverse reactions in the groups A, B, C and D were 4.3%, 9.1%, 18.2%, 27.3% %, The difference was statistically significant (P <0.05). Conclusion Different doses of progesterone treatment of anovulatory menstrual disorders can get good results, but low doses of progesterone produced fewer adverse reactions, higher value.