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探讨HLA DRB1*1501和DQB1*0602与新疆维吾尔、汉族妇女HPV感染及宫颈癌发生的相关性。PCR-SSP和PCR检测287例浸润性宫颈癌(维族192例,汉族95例)及297例正常宫颈组织(维族203例,汉族94例)中DRB1*1501和HLADQB1*0602的分布频率和HPV16 DNA。维族HPV16阳性NILM组中DRB1*1501基因频率高于HPV16阴性NILM组(OR,2.222;95%CI,1.107~4.461;P=0.023),差异有统计学意义;在维族ISCC组及HPV16阳性ISCC组中DQB1*0602基因频率均低于对照组(OR,0.484;95%CI,0.324~0.722;P=0.000;OR,0.552;95%CI,0.360~0.845;P=0.006),差异有统计学意义;汉族ISCC组中DRB1*1501等位基因及DRB1*1501~DQB1*0602单体型均低于对照组(分别为OR,0.305;95%CI,0.115~0.813;P=0.013和OR,0.274;95%CI,0.086~0.874;P=0.021),差异有统计学意义。携带DRB1*1501等位基因为新疆维族妇女HPV16易感基因。DQB1*0602基因可能是新疆维族妇女宫颈癌的保护基因,而DRB1*1501基因及DRB1*1501~DQB1*0602单体型则可能是新疆汉族妇女宫颈癌的保护基因。
To investigate the correlation between HLA DRB1 * 1501 and DQB1 * 0602 and HPV infection and cervical cancer in Uighur and Han women in Xinjiang. The frequencies of DRB1 * 1501 and HLADQB1 * 0602 in 287 invasive cervical cancer (Uygur 192, Han 95) and 297 normal cervix (Uygur 203, Han 94) were detected by PCR-SSP and PCR. . The frequency of DRB1 * 1501 gene in Uighur HPV16 positive NILM group was significantly higher than that in HPV16 negative NILM group (OR, 2.222; 95% CI, 1.107-4.461; P = 0.023) The frequency of DQB1 * 0602 gene was lower than that of the control group (OR, 0.484; 95% CI, 0.324-0.722; P = 0.000; OR, 0.552; 95% CI, 0.360-0.845; ; Han Chinese ISCC group DRB1 * 1501 allele and DRB1 * 1501 ~ DQB1 * 0602 haplotype were lower than the control group (OR, 0.305; 95% CI, 0.115 ~ 0.813; P = 0.013 and OR, 0.274; 95% CI, 0.086 ~ 0.874; P = 0.021), the difference was statistically significant. Carrying DRB1 * 1501 allele as HPV16 susceptibility gene in Uighur women in Xinjiang. The DQB1 * 0602 gene may be the protective gene of cervical cancer in Uyghur women in Xinjiang, while the DRB1 * 1501 gene and DRB1 * 1501 ~ DQB1 * 0602 haplotype may be the protective genes of cervical cancer in Han women in Xinjiang.