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美国有学者称上世纪80年代的他汀类降脂药可以和40年代的青霉素相媲美,称之为他汀类的新纪元。他汀类药物最早是由Endo等人从桔青霉素菌的培养液中分离出的菌株。这类药物是羟甲戊二酰辅酶A还原酶(HMG-CoA)抑制剂,可抑制胆固醇在体内的生物合成,降低LDL-C,使血浆内胆固醇浓度下降。该类药物目前是降低血清胆固醇的首选药物。
Some scholars in the United States said that the statin lipid-lowering drugs of the 1980s can be compared with the penicillin of the 1940s, calling it a new era in statins. Statins were the first to be isolated by Endo et al. From culture broth of citrinin. These drugs are hydroxymethylglutaryl coenzyme A reductase (HMG-CoA) inhibitors, can inhibit cholesterol in vivo biosynthesis, lower LDL-C, the plasma cholesterol concentration decreased. These drugs are currently the drug of choice for lowering serum cholesterol.